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KMID : 0356219950260010061
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Journal of the Korean Military Medical Association
1995 Volume.26 No. 1 p.61 ~ p.67
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Microscopic changes of rabbit liver on acute hypoxia during hypobaric chamber flight
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Abstract
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Disturbance in the vascular supply or venous drainage of the liver under hypoxic exposure are extremely common, but these conditions do not produce significant liver dysfunction. At the other extreme are rare but fat
al hepatic vein thrombosis and
hepatic failure.
The study that acute hypobacin hypoxia alters microscopic changes of liver in rabbit has been investigated. In order to study of microscopic changes of liver in rabbit, author used hypobaric chamber which flew 25,000ft and 34,000ft for 2 hour per
day.
The experimented period was 2 weeks. 10 rabbits were exposed to 25,000ft and 3,000ft, and following results were obtained.
1. 25,000ft experimental group: Gross findings of liver were nonspecific. The microscopic changes of liver showed the well preserved lobular architecture. The central vein showed slightly dilatation with congestion. The portal tracts consisted
of
portal triad which was congested, but acute and chronic inflammatory infiltrates and fibrosis were not founded.
2. 34,000ft experimental group: Groos findings of liver were nonspecific. The microscopic changes showed partly obliterated lobular architectures which consisted of significantly congested central veins, sinusoidal congestion, and expanded
portal
tracts associated with congestion. Especially, sinusoids around central vein were markedly dilated and congested, but hemorrhage and necrosis were not founded. The hepatocytes showed slightly swelled and focal vacuolar cytoplasms.
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